10） 梅野博仁：HPV・EBVと頭頸部腫瘍．耳鼻喉頭頸84：634─640, 2012.11） 大山 勝，吉田 茂，河野もと子：ラリンゴマイクロサージャリー 喉頭パピローマ．JOHNS 8：475─479, 1992.12） Pawlita M, Gissmann L：Recurrent respiratory papillomatosis：Indication for HPV vaccination? Dtsh Med Wochenschr 134：100─102, 2009.13） 松崎洋海，牧山 清，工藤逸大・他：喉頭鏡下喉頭手術におけるHo：YAGレーザーの臨床応用．喉頭；28：1─4, 2016.14） 立岡英宏，岩村 忍，竹内貴志子・他：成人喉頭乳頭腫14例の臨床経験．日耳鼻88：1391, 1985.15） 平野 滋：マイクロフラップ法．喉頭24：90─92, 2012.16） 大木和明，福田宏之，蓼原東紅・他：当院における喉頭乳頭腫の統計的観察．日気食会報12：189─190, 1988.17） 中澤詠子，甲能直幸，西谷全弘・他：当院におけJ. Jpn. Bronchoesophagol. Soc., 73 : 1─7, 2022Laryngeal papilloma is a neoplastic disease of the larynx often showing human papillomavirus （HPV） infection. Although histologically benign, the disease is known to have a high recurrence rate, with malignant transformation occurring in a few percent of cases, making it one of the most intractable diseases. At our hospital, YAG laser cauterization with laryngeal microsurgery is our first choice of treatment. In the present study, we retrospectively reviewed 61 cases of laryngeal papilloma surgically treated at our hospital during the 14-year period from June 2005 to October 2019. The mean age was 51.9±19.7 years, with males dominant: 40 males to 21 females. The av-erage number of treatments was 2.3 （single-occurrence: 1 to 6 times；multiple-occurrence: 1 to 17 times）. The mean follow-up from final treatment was 36±31 weeks. The absence of recurrence af-ter a single treatment occurred in 34 cases and recurrence after the initial treatment occurred in 24 cases. Among the recurrence cases, 6 had residual disease after multiple surgeries. Pathological findings showed 3 cases of malignant transformation. From the results of this study, it is possible that differences in HPV viral types may emerge in refractory cases, suggesting the need for the introduction of viral testing. In addition, there are few reports on the efficacy of adjuvant therapy in Japan, so further evidence needs to be collected.Key words : laryngeal papilloma, treatment, human papillomavirus7る喉頭乳頭腫の検討 in situ HybridizationによるHuman Papillomavirusの検索．喉頭6：49─54, 1994.18） Lindeberg H, Syrjanen S, Karja J, et al：Human papillomavirus type 11 DNA in squamous cell car-cinomas and preexisting multiple laryngeal papil-lomas. Acta Otolaryngol 107：141─149, 1989.19） Harada H, Miura K, Tsutsui Y, et al：Solitary squamous cell papilloma of lung 40-years-old woman with recurrent laryngeal papillomatosis. Pathol Int 50：431─439, 2000.20） 紫野正人：小児喉頭乳頭腫とHPVワクチン．The Kitakanto Medical Journal 68：299─300, 2018.21） Förster G, Boltze C, Seidal J：Juvenile laryngeal papillomatosis─immunisation with the polyvalent vaccine gardasil. Laryngorhinootologie 87：796─799, 2008.22） Human papillomavirus vaccines：WHO position paper, October 2014. Wkly Epidemiol Rec 89（43）：465─491, 2014.日気食会報，73（1），2022Clinical Review of 61 Cases of Laryngeal Papilloma Treated Surgically in Our Hospital1）Department of Otorhinolaryngology-Head & Neck Surgery, National Center for Global Health and Medicine, TokyoYukiko Sagara, M.D.1）, Katsuhiro Tsutsumiuchi, M.D.1）, and Niro Tayama, M.D., Ph.D.1）
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